Who Funds Biotech Startups in North Carolina?

12 venture funds, 6 angel networks, 6 accelerator programs and 6 active federal grants for biotech founders in North Carolina — sourced from SEC Form D filings and Grants.gov.

49
VC Funds Based in North Carolina
$2.2B
Capital in SEC Form D Filings
3
New Fund Filings (12 mo)

Venture Capital Funds Investing in BiotechNorth Carolina

Location
Asheville, NC
Fund Size (Form D)
$10M
Stage Focus
seed
Typical Check
$250K - $750K (typical: $500K)
Latest SEC Filing
May 7, 2025
Location
CHAPEL HILL, NC
Fund Size (Form D)
$10M
Stage Focus
seed
Typical Check
$117K - $351K (typical: $234K)
Latest SEC Filing
May 23, 2024
Location
CHARLOTTE, NC
Fund Size (Form D)
Undisclosed
Typical Check
$500K - $1.5M (typical: $1.0M)
Latest SEC Filing
May 17, 2024
Location
OAK RIDGE, NC
Fund Size (Form D)
$25M
Stage Focus
seed
Typical Check
$341K - $1.0M (typical: $682K)
Latest SEC Filing
Dec 20, 2023
Location
CARY, NC
Fund Size (Form D)
$20M
Stage Focus
seed
Typical Check
$500K - $20M
Latest SEC Filing
Dec 30, 2022
Location
CARY, NC
Fund Size (Form D)
Undisclosed
Typical Check
$500K - $1.5M (typical: $1.0M)
Latest SEC Filing
Oct 11, 2022
Location
CHARLOTTE, NC
Fund Size (Form D)
Undisclosed
Latest SEC Filing
Sep 22, 2022
Location
CHAPEL HILL, NC
Fund Size (Form D)
$30M
Stage Focus
seed
Typical Check
$409K - $1.2M (typical: $818K)
Latest SEC Filing
May 5, 2022
Location
Raleigh, NC
Fund Size (Form D)
$35M
Stage Focus
seed
Typical Check
$477K - $1.4M (typical: $955K)
Latest SEC Filing
Feb 7, 2022
Location
DURHAM, NC
Fund Size (Form D)
$125M
Stage Focus
multi-stage
Latest SEC Filing
Feb 2, 2022
Location
DURHAM, NC
Fund Size (Form D)
$50M
Stage Focus
growth
Typical Check
$100K - $25M
Latest SEC Filing
Jan 4, 2022
Location
Raleigh, NC
Fund Size (Form D)
Undisclosed
Latest SEC Filing
Dec 28, 2021

Angel Networks in North Carolina

Council for Entrepreneurial Development Angels

Location
Durham, NC
Members
100
Avg Check
$35K
Website →

Duke Angels

Location
Durham, NC
Members
80
Avg Check
$50K
Website →

Carolina Angel Network

Location
NC
Members
75
Avg Check
$25K
Website →

xElle Ventures

Location
NC
Members
71
Avg Check
$25K
Website →

Wolfpack Investor Network

Location
NC
Members
70
Avg Check
$25K
Website →

RTP Angel Fund

Location
NC
Members
69
Avg Check
$25K
Website →

Accelerators & Startup Programs for Biotech Founders

Black Ambition

Black Ambition

Funding: $1M

Apply →

Elemental Impact

Elemental Impact

Funding: $1M

Apply →

Lemnos

Lemnos

Funding: $500K

Apply →

Y Combinator

Y Combinator

Funding: $500K

Apply →

Alliance DAO

Alliance DAO

Funding: $250K – $500K

Apply →

Contrary Capital

Contrary Capital

Funding: $500K

Apply →

See the full accelerator directory for industry-specific programs.

Active Federal Grant Opportunities

Statewide Consumer Network

Substance Abuse and Mental Health Services Adminis

Award
Undisclosed – $150K
Deadline
Jun 24, 2026
View on Grants.gov →

U.S. STEM Summer Exchange for Youth

U.S. Mission to the Dominican Republic

Award
$30K – $80K
Deadline
Jun 24, 2026
View on Grants.gov →

FY 2026 Pipeline One-Call Grant

Pipeline and Hazardous Materials Safety Admin

Award
$100.00 – $60K
Deadline
Jun 24, 2026
View on Grants.gov →

BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional)

National Institutes of Health

Deadline
Jun 24, 2026
View on Grants.gov →

FY 2026 State Damage Prevention

Pipeline and Hazardous Materials Safety Admin

Award
$4K – $100K
Deadline
Jun 24, 2026
View on Grants.gov →

Center of Excellence on Eating Disorders

Substance Abuse and Mental Health Services Adminis

Award
Undisclosed – $2M
Deadline
Jun 24, 2026
View on Grants.gov →

Browse all federal startup grants with deadlines and eligibility.

Data sources: Fund data comes from SEC Form D filings (EDGAR), updated nightly. Grant opportunities come from Grants.gov. Angel network and accelerator data is curated from public sources. Figures shown are the amounts reported in regulatory filings, not estimates. Last refreshed June 2026.